The Effects of Polyethylene Glycol (PEG-600) On the Acute Neurotoxicity of Different Types of Pesticides

Pesticides intoxication has been implicated in many toxic diseases, and agricultural adjuvants including polyethylene glycols are used in a variety of applications including industrial manufacturing. The aim of this study was to analyze the effect of PEG-600 on the biochemical toxic effects of malathion, imiprothrin and imidacloprid on the basis of the determined LD50 values on the quails (Coturnix coturnix). In the present study the toxic effect of the tested pesticides was characterized by a clear disturbances in the activity ofplasma alkaline phosphatase (ALP), transaminases (AST, ALT), acetylcholinesterase ( AChE) and total contents , as well the concentrations of brain glutamate, aspartate, GABA, glycine, norepinephrine and dopamine concentrations. PEG-600 treatment did not change blood biochemical parameters but significantly increases the concentrations of whole brain studied amino acids and catecholamines In addition, the combination of PEG-600 with the tested pesticides acts synergistically on reducing the recorded LD50 values of malathion, imidacloprid and imiprothin in Coturnix coturnix by -32.247, -41.529 and -11.026 ; attenuates more toxic symptoms, modulates more changes in the activity of plasma AChE, ALP ,AST, and ALT and attenuates more decreased effect in the concentration of the brain dopamine and norepinephrine, and potentiate more toxic effects of the studied pesticides on the concentration of the free studied amino acids. .These results could indicate the toxic effect of polyethylene glycol to birds and is also potentiate the neuronal toxic effect of pesticides exposure